Physiological Roles of DNA Double-Strand Breaks

Genomic integrity is constantly threatened by sources of DNA damage, internal and external alike.Among the most cytotoxic lesions is the DNA double-strand break (DSB) which arises from the cleavage of both strands of the double helix.Cells boast a considerable set of defences to both prevent and repair these breaks and drugs which derail these proc

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A university map of course knowledge

Knowledge representation has gained in relevance as data from the ubiquitous digitization of behaviors amass and academia and industry seek methods to understand and reason about the information they encode.Success in this pursuit has emerged with data from natural language, where skip-grams and other linear connectionist models of distributed repr

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Recurrent cerebellar ischemic infarctions and stereotyped peri-ictal sympathetic responses in a near-SUDEP patient with cardiovascular risk factors

We report a 60-year-old woman who presented to the emergency department after experiencing a witnessed unknown onset bilateral tonic clonic seizure (GTCS) that culminated in cardiac arrest.A neurology consultant uncovered a years-long history oil blotting paper of frequent episodic staring followed by confusion and expressive aphasia, which strongl

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